Nanomedicines for the treatment of severe diseases
Major Publications
Bekkra-Aounallah F., Ambike A., Gref R., Couvreur P., Rosilio V. - Interfacial behavior
of PEGylated lipids and their effect on the stability of squalenoyl-drug nanoparticles.
Int. J. Pharm. 471, 75-82, 2014
Lepeltier E., Bourgaux C., Maksimenko A., Meneau F., Rosilio V., Zouhiri F., Desmaele D., Couvreur P. -
Self-assembly of polyisoprenoyl
gemcitabine conjugates: influence of supramolecular organization on their biological activity.
Langmuir, 30, 6348-6357, 2014
Lepeltier E., Bourgaux C., Couvreur P. - Nanoprecipitation and the "Ouzo effect":
Application to drug delivery devices. Advanced Drug Delivery Reviews, 71, 86-97, 2014
Bourgaux C., Couvreur P. - Interaction of anticancer drugs with biomembranes :
What can we learn from model membranes ? J Controlled Release, 190, 127-138, 2014
Maksimenko A., Dosio F., Mougin J., Ferrero A., Wack S., Reddy L.H., Weyn A.A., Lepeltier E., Bourgaux C.,
Stella B., Cattel L., Couvreur P. - A unique squalenoylated and non pegylated doxorubicin nanomedicine
with systemic long-circulating properties and anticancer activity. PNAS, 111, 2, E217-E226, 2014
Ralay-Ranaivo B., Desmaële D., Bianchini E., Lepeltier E., Bourgaux C., Borgel D., Pouget T., Tranchant J.F.,
Couvreur P., Gref R. - Novel self assembling nanoparticles for the oral administration of fondaparinux: synthesis,
characterization and in vivo evaluation. J. of Control. Release, 194, 323-331, 2014
Agsotoni V., Chalati T., Horcajada P., Willaime H., Anand R., Semiramoth N., Baati T., Hall S., Maurin G.,
Chacun H., Bouchemal K., Martineau C., Tautelle F., Couvreur P., Rogez-Kreuz C., Clayette P., Monti S., Serre V.,
Gref R. - Towards an improved anti-HIV activity of NRTI via metal organic frameworks nanoparticles. Advanced Healthcare Materials.
doi: 10.1002/adhm.201200454
Diou O., Fattal E., Delplace V., Mackiewicz N., Nicolas J., Meriaux S., Valette J., Robic C., Tsapis N. –
RGD decoration of PEGylated polyester nanocapsules of perfluorooctylbromide for tumor imaging: Influence
of pre or post-functionalization on capsule morphology. European Journal of Pharmaceutics and Biopharmaceutics, 87, 170-171, 2014
Fattal E., Grabowski N., Mura S., Vergnaud J., Tsapis N., Hillaireau H. - Lung toxicity of biodegradable nanoparticles. J. Biomed.
Nanotech., 10, 2852-2864, 2014
Raouane M., Hafiz A., Maksimenko A., Rubinati G., Desmaële D., Yasuhiro H., Harashima H., Couvreur P., Massade L. –
Effects of silencing RET/PTC1 oncogene in papillary thyroid carcinoma by siRNA-squalene nanoparticles with and without
fusogenic companion GALA-cholesterol. Thyroid, 24, 327-338 , 2014
Caron J., Maksimenko A., Mougin J., Couvreur P., Desmaële D. - Combined antitumoral therapy with nanoassemblies of holaform polyisoprenoyl paclitaxel/gemcitabine prodrugs. Polymer Chemistry, 5, 1662-1673, 2014
Trung Bui D., Nicolas J., Maksimenko A., Desmaële D., Couvreur P. - Multifunctional squalene-based prodrug nanoparticles for targeted cancer therapy. Chemical Communications, 50, 5336-5338, 2014
Lepeltier E., Bourgaux C., Couvreur P. - Nanoprecipitation and the "Ouzo effect": Application to drug delivery devices. Advanced Drug Delivery Reviews, 71, 86-97, 2014
Maksimenko A., Dosio F., Mougin J., Ferrero A., Wack S., Harivardhan Reddy L., Weyn A., Lepeltier E., Bourgaux C., Stella B., Cattel L., Couvreur P. - Squalenoylated Doxorubicin: a New Long Circulating and Non Pegylated Anticancer Nanomedicine. Proceeding Nat1. Acad. Sci., USA, 111, E217-E226, 2014
Kozlu S., Caban S., Yerlikaya F., Fernandez-Megia E., Novoa-Carballal R., Riguera R., Yemisci M., Gursoy-Ozdemir Y., Dalkarat T., Couvreur P., Capan Y. - An aquaporin 4 antisense oligonucleotide loaded, brain targeted nanoparticulate system design. Pharmazie, 69, 340-345, 2014
Ozturk K., Fernandez-Megia E., Novoa-Caballal R., Riguera R., Yemisci M., Gursoy-Ozdemir Y., Dalkara T., Couvreur P., Capan Y. - Comparative in vitro studies on PBN loaded nanoparticles prepared by biodegradable chitosan, PLGA polymers and their PEGylated block copolymers. J. Drug Del. Sci. Tech., 24, 148-152, 2014
Bekkara-Aounallah F., Ambike A., Gref R., Couvreur P., Rosilio V. - Interfacial behavior of PEGylated lipids and their effect on the stability of squalenoyl-drug nanoassemblies. Int. J Pharm, 471, 75-82, 2014
Ali Hafiz M., Urbinati G., Chapuis H., Desmaële D., Bertrand J.R., Couvreur P., Massade L. - Effects of siRNA on RET/PTC3 Junction Oncogene in Papillary Thyroid Carcinoma: From Molecular and Cellular Studies to Preclinical Investigations. PLOS, 9, e95964, 2014
Grimaldi E., Couvreur P., Benoît J.P., Fanciullino R., Sergent J.A., Van Miert E., Pourroy B., Meshaka P., Brescianini A., Corvaia N., Haeuw J.F., Goetsch L., Beck A. - High-technology drugs in oncology. Oncologie, 16, 379-387, 2014
Delplace V., Couvreur P., Nicolas J. - Recent trends in the design of anticancer polymer prodrug nanocarriers. Polymer Chemistry, 5, 1529-1544, 2014
Cheikh-Ali Z., Caron J., Cojean S., Bories C., Couvreur P., Loiseau P.M., Desmaële D., Poupon E., Champy P. - Squalenoylcurcumin" Nanoassemblies as Water-Dispersible Drug Candidates with Antileishmanial Activity. ChemMedChem., doi: 10.1002/cmdc.201402449, 2014
Skarbek C., Lesueur L., Chapuis H., Deroussent A., Pioche-Durieu C., Daville A., Caron J., Rivard M., Martens T., Bertrand J., Le Cam E., Vassal G., Couvreur P., Desmaële D., Paci A. - Preactivated Oxazaphosphorines Designed for Isophosphoramide Mustard Delivery as Bulk Form or Nanoassemblies: Synthesis and Proof of Concept. J. Med. Chem., DOI: 10.1021/jm501224x, 2014
Yemisci M., Caban S., Gursoy-Ozdemir Y., Lule S., Novoa-Carballal R., Riguera R., Fernandez-Megia E., Ancrieux K., Couvreur P., Capan Y., Dalkara T. - Systemically administered brain-targeted nanoparticles transport peptides across the blood-brain barrier and provide neuroprotection. J Cereb Blood Flow Metab. doi: 10.1038/jcbfm.2014.220. 2014 Dec 10
Ralay-Ranaivo B., Desmaële D., Bianchini E.P., Lepeltier E., Bourgaux C., Borgel D., Pouget T., Tranchant J.F., Couvreur P., Gref R. - Novel self assembling nanoparticles for the oral administration of fondaparinux: Synthesis, characterization and in vivo evaluation. J Controlled Release, 194, 323–331 2014
Maksimenko A., Trung Bui D., Couvreur P., Nicolas J. - Significant tumor growth inhibition from naturally occurring lipid-containing polymer prodrug nanoparticles obtained by the drug initiated method. Chemistry of Materials, 26, 3606-3609, 2014
Maksimenko A., Caron J., Mougin J., Desmaële D., Couvreur P. - Gemcitabine based therapy for pancreatic cancer using the squalenoyl nucleoside monophosphate nanoassemblies. Int J Pharm, http://dx.doi.org/10.1016/j.ijpharm.2014.11.009, 2014
Abed N., Couvreur P. - Nanocarriers for antibiotics, a promising solution to treat intracellular bacterial infections. Internat. J Antimicrobial Agents, 43, 485-496, 2014
Bourgaux C., Couvreur P. - Interaction of anticancer drugs with biomembranes : What can we learn from model membranes ? J Controlled Release, 190, 127-138, 2014
Valetti S., Mura S., Noiray M., Arpicco S., Dosio F., Vergnaud J., Desmaële D., Stella B., Couvreur P. - Peptide conjugation : before or after nanoparticle formation ? Bioconjugate Chemistry, 25, 1971-1983, 2014
Couvreur P. - Patrick Couvreur: inspiring pharmaceutical innovation. Nanomedicine, 9, 759-761, 2014
Valetti S., Maione F., Mura S., Stella B., Desmaële D., Noiray M., Vergnaud J., Vauthier C., Cattel L., Giraudo E., Couvreur P. - Peptide-functionalized nanoparticles for selective targeting of pancreatic tumor. J Controlled Release, 192, 29-39, 2014
Lepeltier E., Bourgaux C., Maksimenko A., Meneau F., Rosilio V., Sliwinski E., Zouhiri F., Desmaële D., Couvreur P. - Self-assembly of polyisoprenoyl gemcitabine conjugates: Influence of supramolecular organization on their biological activity. Langmuir, 30, 6348-6357, 2014
Mackiewicz N., Nicolas J., Hanke N., Noiray M., Mougin J., Daveu C., Lakkireddy H.R., Bazile D., Couvreur P. - Precise engineering of multifunctional PEGylated polyester nanoparticles for cancer cell targeting and imaging. Chemistry of Materials, 26, 1834-1847, 2014
Couvreur P. - Replenishing reservoirs in vivo. Nature Nanotechnology, 9, 874-875, 2014
Maksimenko A., Alami M., Zouhiri F., Brion J.D., Pruvost A., Mougin J., Hamze A., Boissenot T., Provot O., Desmaële D., Couvreur P. - Therapeutic modalities of squalenoyl nanocomposites in colon cancer: an ongoing search for improved efficacy. ACS Nano, 8, 2018-2032, 2014
Gaudin A., Yemisci M., Eroglu H., Lepetre-Mouelhi S., Turkoglu O.F., Donmez-Demir B., Caban S., Sargon M.F., Garcia-Argote S., Pieters G., Loreau O., Rousseau B., Tagit O., Hildebrandt N., Le Dantec Y., Mougin J., Valetti S., Chacun H., Nicolas V., Desmaële D., Andrieux K., Capan Y., Dalkara T., Couvreur P. - Squalenoyl Adenosine Nanoparticles provide Neuroprotection after Stroke and Spinal Cord Injury. Nature Nanotechnology, 9, 1054-1063, 2014 (IF: 33.26)
Dellagi A., Aznar A., Chen, N.W. G., Rigault M., Riache N., Joseph D., Desmaële D., Mouille G., Boutet S., Soubigou-Taconnat L Renou, J.-P,. Thomine, S. Expert D. - Scavenging iron: a novel mechanism of plant immunity activation by microbial siderophores. Plant Physiol., 164, 2167-2180, 2014.
Collery P., Bastian G., Santoni F., Mohsen A., Wei M., Collery T., Tomas A., Desmaële D., D’Angelo J. - Uptake and Efflux of Rhenium in Cells Exposed to Rhenium Diseleno-Ether and tissue Distribution of Rhenium and Selenium after Rhenium Diseleno-Ether Treatment in Mice. Anticancer Research, 34, 1679-1690, 2014
Harrisson S., Nicolas J. - In the (Very) Long Run We Are All Dead: Activation and Termination in SET-LRP/SARA-ATRP. ACS Macro Lett., 3, 643, 2014
Delplace V., Harrisson S., Tardy A., Gigmes D., Guillaneuf Y., Nicolas J. - Nitroxide-Mediated Radical Ring-Opening Copolymerization: Chain-End Investigation and Block Copolymer Synthesis. Macromol. Rapid Commun., 35, 484, 2014